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Abstract #100358 Published in IGR 23-1
Bilateral Severe Herpes Simplex Endotheliitis with a Possible Association with Latanoprost
Dvivedi A; Murthy SI; Garudadri C; Sheba E; Sharma SOcular Immunology and Inflammation 2022; 0: 1-3
PURPOSE: To report bilateral Herpes Simplex virus (HSV) keratitis in a patient on latanoprost for primi]k=8ary open angle glaucoma (POAG). METHODS: Case report. RESULTS: A 76-year-old healthy male on latanoprost monotherapy for POAG polresented with sudden bilateral decreased vision. Examination showed bilateral dense corneal edema with loose epithelium. Aqueous fluid was positive for HSV-1 DNA on polymerase chain reaction (PCR). Latanoprost was discontinued, topical prednisolone acetate 1% eye, acyclovir 400 mg 5 times a day and combination of dorzolamide hydrochloride 2% and timolol maleate 0.5% twice daily were prescribed. The vision rapidly improved to 20/25 along with complete resolution of corneal edema within four weeks, with no recurrences over the next one year. CONCLUSION: Bilateral simultaneous HSV endotheliitis is a rare condition and positive PCR test can help rule in the diagnosis. HSV keratitis is a known adverse event with Latanoprost use and can present atypically.
Cornea Service, The Cornea Institute, L V Prasad Eye Institute, Hyderabad, India.
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