advertisement
Abstract #100423 Published in IGR 23-1
Associated Factors and Distribution of Peripapillary Retinal Nerve Fiber Layer Thickness in Children by Optical Coherence Tomography: A Population-based Study
Hashemi H; Khabazkhoob M; Heydarian S; Emamian MH; Fotouhi AJournal of Glaucoma 2022; 31: 666-674
PURPOSE: To determine the distribution of peripapillary retinal nerve fiber layer (RNFL) thickness and its association with different demographic and ocular parameters in adolescents. METHODS: The present study is part of the second phase of the Shahroud Schoolchildren Eye cohort study, which was conducted in 2018 by re-inviting the participants in the first phase. First, preliminary ocular examinations were performed, including measurement of uncorrected and best corrected visual acuity, auto-refraction, and subjective refraction.All study participants underwent corneal imaging using Pentacam to measure central corneal thickness and corneal radius of curvature (keratometry), ocular biometry using Allegro Biograph to measure anterior chamber depth, crystalline lens thickness, and axial length, and finally OCT imaging to measure RNFL thickness as well as macular thickness and volume. RESULTS: The data of 4963 right eyes were analyzed after applying the exclusion criteria. The mean age of the study participants was 12.41±1.72 (9 to 15) years. The mean total, superior, inferior, temporal, and nasal RNFL thicknesses were 98.93 (95% CI: 98.61-99.25), 122.84 (95% CI: 122.31-123.37), 129.17 (95% CI: 128.63-129.7), 68.02 (95% CI: 67.65-68.38), and 75.69 (95% CI: 75.3-76.07), respectively. According to the results of the multivariable regression model, macular volume (β=9.81,P=0.001] had a significant direct association, and macular thickness (β=-0.01,P=0.046) had a significant inverse association with the average RNFL thickness. In addition, axial length (β=-3.14,P<0.001), mean keratometry (β=-1.38,P<0.001], and central corneal thickness (β=-0.01,P=0.011) were significantly inversely related to the average RNFL thickness. CONCLUSION: We report the distribution of peripapillary RNFL thickness using SD-OCT and identify macular volume, axial length, and mean keratometry as significantly associated factors in children. Our findings may serve as a database to interpret RNFL thickness results in children aged 9 to 15 years with suspected ocular disease.
Noor Research Center for Ophthalmic Epidemiology, Noor Eye Hospital, Tehran, Iran.
Full article