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Abstract #100427 Published in IGR 23-1
Diagnostic Performance of Optical Coherence Tomography for Pseudoexfoliation Glaucoma
Ozcelik-Kose A; Yıldız MB; Imamoglu SJournal of Glaucoma 2022; 31: 651-658
PRECIS: LC thickness and LCCI had comparable diagnostic performances with RNFL thickness in distinguishing eyes with PXG from those with PXS. BMO-MRW showed the lowest diagnostic performance among all geometric parameters derived from OCT scans we evaluated. OBJECTIVE: To compare the diagnostic performance of different geometric parameters derived from optical coherence tomography (OCT) scans (retinal nerve fiber layer [RNFL] thickness, lamina cribrosa [LC] thickness, LC curvature index [LCCI] and Bruch's membrane opening-minimum rim width [BMO-MRW]) for distinguishing eyes with pseudoexfoliation glaucoma (PXG) from pseudoexfoliation syndrome (PXS) and healthy eyes. METHODS: Fifty-five eyes of 55 patients with PXG, 55 eyes of 55 patients with PXS, and 50 healthy subjects were enrolled in this cross-sectional study. The areas under the receiver operating characteristic curves (AUCs) of RNFL thickness, LC thickness, LCCI and BMO-MRW were calculated and compared. RESULTS: In discriminating between eyes with PXG from those with PXS, LC thickness (0.930 [95% CI: 0.883-0.978]) and global RNFL thickness (0.974 [95% CI: 0.947-0.992]) presented comparable AUCs (P=0.244). In distinguishing subjects wiht PXG from healthy controls, both LC thickness (0.972 [95% CI: 0.948-0.997]) and LCCI (0.983 [95% CI: 0.968-0.998]) had comparable AUCs with global RNFL thickness (0.988 [95% CI: 0.974-1.000]) (P=0.094 andP=0.239, respectively). Global BMO-MRW had lower AUCs than RNFL thickness (0.839 [95% CI: 0.759-0.920] and 0.897 [95% CI: 0.836-0.958], respectively) in distinguishing PXG from both PXS and healthy controls (P=0.001 andP=0.002, respectively). BMO-MRW also had significantly lower AUCs than both LC thickness and LCCI in distinguishing PXG from healthy controls (P=0.034 andP=0.001, respectively). CONCLUSION: LC thickness and LCCI had better diagnostic performance than BMO-MRW in distinguishing PXG from PXS and healthy controls, which were comparable to RNFL thickness.
University of Health Sciences Haydarpasa Education and Research Hospital, Department of Ophthalmology, Istanbul, Turkey.
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