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Abstract #10058 Published in IGR 6-1
Determinants of eye drop size
Van Santvliet L; Ludwig ASurvey of Ophthalmology 2004; 49: 197-213
Ophthalmic solutions are available for multidose or single-dose administration in a wide variety of glass and plastic dropper bottles which deliver drops with a volume between 25 and 70 μl. From a biopharmaceutical and economic point of view, however, smaller volumes of 5-15 μl should be instilled. In this review, the technical, pharmaceutical, and therapeutic aspects of eye drop formation and delivery are presented. The different types of containers are described and the determinants of eye drop size are discussed, such as the design and physical characteristics of the dropper tip and bottle, the physico-chemical properties of the solution, and the manner in which the patient dispenses the drops. Preferred and alternative instillation techniques and aids to facilitate the administration of eye drops by elderly patients are described.
Dr. L. Van Santvliet, University of Antwerp (U.I.A.), Laboratory of Pharmaceutical Technology and Biopharmacy, Antwerp, Belgium
Classification:
11.16 Vehicles, delivery systems, pharmacokinetics, formulation (Part of: 11 Medical treatment)