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Abstract #10134 Published in IGR 6-1
Crossover comparison of timolol and latanoprost in chronic primary angle-closure glaucoma
Sihota R; Saxena R; Agarwal HC; Gulati VArchives of Ophthalmology 2004; 122: 185-189
OBJECTIVE: To compare latanoprost and timolol maleate as primary therapy in 60 eyes with chronic primary angle-closure glaucoma after a laser iridotomy. METHODS: The authors performed a prospective, randomized, crossover study in 60 eyes of 30 patients with chronic primary angle-closure glaucoma after laser iridotomy. The patients were randomized to two groups: those taking latanoprost once daily and those taking timolol twice daily. Three months after treatment with the first drug, the second drug was substituted. The circadian rhythm of intraocular pressure (IOP) was recorded before the start of therapy, at three and seven months. The fourth month was the washout period for the first drug. RESULTS: The mean baseline IOP was 23.5 ± 2.1 mmHg, which decreased by 8.2 ± 2.0 mmHg with latanoprost (p < 0.001) and by 6.1 ± 1.7 mmHg with timolol (p = 0.01). The decrease in IOP was greater for patients taking latanoprost (p < 0.001). Latanoprost was significantly more effective in eyes having morning and afternoon peaks of IOP. A total of 43 eyes (72%) of patients taking latanoprost and 26 (43%) on timolol achieved a reduction of more than 30% from baseline IOP. CONCLUSION: There were greater mean and peak IOP reductions achieved with 0.005% latanoprost once daily compared with 0.5% timolol twice daily.
Dr. R. Sihota, Centre for Opthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India. rjsihota@hotmail.com
Classification:
11.3.4 Betablocker (Part of: 11 Medical treatment > 11.3 Adrenergic drugs)
11.4 Prostaglandins (Part of: 11 Medical treatment)