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Abstract #10153 Published in IGR 6-1
Hypotensive effect and subjective symptoms after substitution of 1% dorzolamide by 1% brinzolamide
Kobayashi H; Kobayashi K; Okinami SJapanese Journal of Clinical Ophthalmology 2004; 58: 205-209
PURPOSE: To compare the hypotensive effect and comfort of 1% brinzolamide and 1% dorzolamide. METHODS: A total of 60 eyes of 60 patients of primary open-angle glaucoma were enrolled in a prospective single-masked clinical study. They had been receiving 0.5% timolol, 0.005% latanoprost, and 1% dorzolamide for three months or longer. In 40 patients, dorzolamide was substituted by brinzolamide. The other 20 patients continued the regimen and served as controls. No significant differences were present between the two groups regarding age, corrected visual acuity, mean deviation in Humphrey perimetry, and cupping/disc ratio. The baseline intraocular pressure (IOP) averaged 18.5 ± 3.4 mmHg in the brinzolamide group and 18.9 ± 2.9 mmHg in the control group. RESULTS: There were no significant differences in IOP four and eight weeks after substitution in either group. No differences were present between IOP levels in the groups up to eight weeks of observation. In the brinzolamide group, 38 patients (95%) preferred brinzolamide 2. i. d. to dorzolamide 3. i. d. CONCLUSIONS: The same hypotensive effect was shown by 1% brinzolamide and 1% dorzolamide. Brinzolamide may improve compliance because of its reduced frequency of instillation. LA: Japanese
Dr. H. Kobayashi, Department of Ophthalmology, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga 849-8501, Japan
Classification:
11.5.2 Topical (Part of: 11 Medical treatment > 11.5 Carbonic anhydrase inhibitors)
