advertisement
Abstract #10198 Published in IGR 6-1
Systemic anti-inflammatory fibrosis suppression in threatened trabeculectomy failure
Vote B; Fuller JR; Bevin TH; Molteno ACClinical and Experimental Ophthalmology 2004; 32: 81-66
PURPOSE: To provide a rationale for the use of systemic anti-inflammatory fibrosis suppression in the postoperative management of threatened early trabeculectomy bleb failure. METHODS: A review of the literature and of the authors' own experiences was conducted. RESULTS: The most important cause of persistent elevation of intraocular pressure after trabeculectomy is unduly marked or persistent inflammation with deposition of fibrous tissue, which prevents the formation of an adequately draining bleb. It was found that a clinically useful degree of suppression of bleb inflammation and fibrosis can be obtained with a four to six week course of the combined systemic administration of prednisone (10 mg t.i.d.), a non-steroidal anti-inflammatory agent (e.g., diclofenac 100 mg SR daily) and colchicine (0.25 or 0.3 mg t.i.d.), which was termed anti-inflammatory fibrosis suppression. Topical atropine 1% t.i.d. and adrenaline 1% t.i.d. eye drops can also be considered in addition to routine postoperative topical steroids. CONCLUSIONS: Despite advances in surgical techniques and methods to control fibrosis, anti-inflammatory fibrosis suppression is a valuable tool to have available in the post-operative period for management of trabeculectomies that threaten failure. This regime produces a diffuse bleb, which has a very low risk of late infection or bleb perforation. It is recommend that this regime be added to the list of therapies that are considered when clinical features suggestive of a failing bleb are confronted early in the postoperative course.
Dr. B. Vote, Department of Ophthalmology, University of Otago Medical School, Dunedin, New Zealand. eye.vote@blueyonder.co.uk
Classification:
12.8.10 Woundhealing antifibrosis (Part of: 12 Surgical treatment > 12.8 Filtering surgery)
