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Abstract #10202 Published in IGR 6-1
The experimental study on Decorin suppressing subconjunctival I or III type collagen after filtration surgery
Xie L; He X; Wu GChinese Ophthalmic Research 2003; 21: 601-604
OBJECTIVE: To elucidate the inhibitory action of Decorin on subconjunctiva scarring, and provide theory bases for the clinical results. METHODS: Reichel's model of conjunctival scarring was used. Thirty-six rabbits (72 eyes) were divided into Decorin group (n = 24), PBS group (n = 24) and normal controls (n = 24). A Schotz ophthalmotonometer was used to measure intraocular pressure (IOP). Sirius Rose BB staining was performed to identify I or III type collagen at different time points. RESULTS: Decorin effectively inhibited conjunctival scarring and kept IOP lower. Expression of I or III type collagen were significantly decreased in the Decorin group. CONCLUSION: As a neutralizing agent, Decorin could reduce subconjunctival scarring after filtration surgery. LA: Chinese
Dr.L. Xie, Department of Ophthalmology, Third Hospital of Third Mil. Medical University, Chongqing 400042, China
Classification:
12.8.10 Woundhealing antifibrosis (Part of: 12 Surgical treatment > 12.8 Filtering surgery)
