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Abstract #10261 Published in IGR 6-1
The confocal scanning laser ophthalmoscopy ancillary study to the ocular hypertension treatment study: study design and baseline factors
Zangwill LM; Weinreb RN; Berry CC; Smith AR; Dirkes KA; Liebmann JM; Brandt JD; Trick G; Cioffi GA; Coleman ALAmerican Journal of Ophthalmology 2004; 137: 219-227
PURPOSE: To describe the study design of the Confocal Scanning Laser Ophthalmoscopy (CSLO) Ancillary Study to the Ocular Hypertension Treatment Study (OHTS) and to examine the associations between optic disc topography, and baseline demographic, clinical, and ocular factors at study entry. DESIGN: A randomized clinical trial. METHODS: Participants in this ancillary study were recruited from seven of the 22 OHTS clinical centers. Each participant completed imaging annually using a CSLO, the Heidelberg Retina Tomograph (HRT). Associations between HRT topographic optic disc measurements and intraocular pressure (IOP), baseline photographic estimates of horizontal and vertical cup-to-disc diameter ratios by the OHTS Optic Disc Reading Center, baseline visual field indices, and demographic and clinical factors were assessed using linear mixed effects models. RESULTS: Four hundred and thirty-nine participants had good quality images and were included in this baseline analysis. No associations between HRT topographic optic disc measurements and diabetes, systemic hypertension, cardiovascular disease, IOP, or visual function were found. The HRT topographic optic disc measurements were associated with baseline stereophotographic estimates of horizontal and vertical cup-to-disc diameter ratios. The strongest associations were found between stereophotographic assessment of horizontal and vertical cup-to-disc diameter ratios, and HRT cup-to-disc area ratio (r = 0.85 and 0.84, respectively), rim-to-disc area ratio (r = -0.85 and -0.84, respectively), mean cup depth (r = 0.84 and.83, respectively), and cup area (r = .83 and.80, respectively). After adjusting for optic disc area, all HRT topographic optic disc measurements remained associated with stereophotographic assessment of horizontal and vertical cup-to-disc diameter ratios. CONCLUSIONS: The CSLO ancillary study to the OHTS is the first multicenter clinical trial to use CSLO imaging to monitor changes in the optic disc. At study entry, HRT topographic measurements corresponded well with both horizontal and vertical stereophotographic-based estimates of cup-to-disc diameter ratio in ocular hypertensive participants.
Dr. L.M. Zangwill, Department of Ophthalmology, University of California at San Diego, La Jolla, CA 92093-0946, USA. zangwill@eyecenter.ucsd.edu
Classification:
2.14 Optic disc (Part of: 2 Anatomical structures in glaucoma)
6.9.1 Laser scanning (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis)