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Abstract #10379 Published in IGR 6-1
Interocular asymmetry of visual field defects in primary open angle glaucoma and primary angle-closure glaucoma
Wang JC; Gazzard G; Foster PJ; Devereux JG; Oen FT; Chew PT; Khaw PT; Seah SKEye 2004; 18: 365-368
AIM: To compare the interocular asymmetry in visual field loss of patients with primary open-angle (POAG) and primary angle-closure glaucoma (PACG). METHODS: Subjects entering a prospective, randomized, controlled trial of intraoperative 5-fluorouracil in glaucoma surgery in Singapore were included. Preoperative visual field testing was performed using automated white-on-white perimetry (24-2 test pattern, threshold program, Mk II, Model 750, Zeiss-Humphrey, San Leandro, CA). A minimum of two tests was required with mean deviation within 2 dB on two tests, fixation losses < 20%, false positives < 33%, and false negatives < 33%. The second field was scored using AGIS II criteria and the 'mean asymmetry score', defined as the mean difference between eyes for both AGIS scores and global indices. RESULTS: In 230 subjects assessed (128 POAG, 102 PACG), mean interocular asymmetry of visual field loss was greater in the PACG group. The mean AGIS asymmetry scores for total (PACG = 9.21 ± 6.87 versus POAG = 6.48 ± 5.58, p = 0.001), superior (PACG = 4.31 ± 3.39 versus POAG = 3.35 ± 3.13, p = 0.035), and inferior (PACG = 4.43 ± 3.31 versus POAG = 2.64 ± 2.77, p < 0.0001) areas and mean deviation (MD) asymmetry scores (PACG = 6.89 ± 13.22 versus POAG = 1.66 ± 16.97, p = 0.012) were all significantly different. Interocular correlation of visual field loss for POAG was significant; total AGIS, r = 0.27 (p = 0.003), superior field AGIS, r = 0.24 (p = 0.008), inferior field AGIS, r = 0.34 (p = 0.0001), and MD, r = 0.27 (p = 0.003). In PACG, there was no significant correlation between eyes; total AGIS, r = -0.02 (p = 0.85), superior field AGIS, r = -0.02 (p = 0.82), inferior field AGIS, r = -0.17 (p = 0.87), and MD, r = 0.015 (p = 0.89). CONCLUSIONS: There was a greater asymmetry of visual field loss between eyes, as measured by AGIS scores and MD, in PACG than that in POAG.
Dr. J.C. Wang, Singapore National Eye Centre, Singapore
Classification:
6.6.2 Automated (Part of: 6 Clinical examination methods > 6.6 Visual field examination and other visual function tests)
9.3.2 Chronic primary angle closure glaucoma (pupillary block) (Part of: 9 Clinical forms of glaucomas > 9.3 Primary angle closure glaucomas)