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Abstract #10395 Published in IGR 6-1
Follow up in open angle glaucoma. A comparison of static perimetry and the fast stimulation mfERG: multifocal ERG follow up in open angle glaucoma
Palmowski AM; Ruprecht KWDocumenta Ophthalmologica 2004; 108: 55-60
PURPOSE: To compare changes in the mfERG to visual field changes observed in open angle glaucoma (OAG). METHODS: Twenty-nine eyes with OAG were included. Visual fields (Octopus d32) and mfERGs (VERIS) were obtained at a mean interval of nine months (SD six months). MfERG recording parameters were as follows: 103 hexagons stimulated the central 50°. M-sequence 2-5, stimulus base interval 13.33 msec, Lmax 200 cd/m2, contrast 99%. First (KI) and second (KII) order response components were analyzed for the individual quadrants of the visual field and compared to the corresponding mean deviation (MD) of the static perimetry. RESULTS: Changes in visual field parameters and changes in the mfERG did not differ significantly. Overall, as mean deviation increased there was a tendency for implicit times to increase and for amplitudes to decrease. However, over the follow-up interval of nine months, only minor changes were observed. The second order response component correlated best with changes in MD (p < 0.05). These were the correlation between MD and KII N1 (r: 0.36) in the upper temporal field, between MD and KII N2 (r: 0.40) in the upper nasal field and between MD and KII P1 (r: 0.38) in the lower temporal field. When a subgroup of ten eyes that had been tested at least three times over 16.8 months (SD 5.5) was examined, still only minor changes were observed in either parameter. CONCLUSIONS: While the changes over time in the mfERG and the visual field showed a reasonable correlation, changes observed in either parameter were extremely small over the time period observed, thus requiring a longer follow-up and/or a more sensitive stimulation technique.
Dr. A.M. Palmowski, Universitatsaugenklinik, 66421 Homburg, Germany. palmowskia@uhbs.ch
Classification:
6.7 Electro-ophthalmodiagnosis (Part of: 6 Clinical examination methods)