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Abstract #10413 Published in IGR 6-1
The effects of menopause and hormone replacement therapy on quality and quantity of tear, intraocular pressure and ocular blood flow
Altintas O; Caglar Y; Yuksel N; Demirci A; Karabas LOphthalmologica 2004; 218: 120-129
OBJECTIVE: To evaluate the effects of menopause and hormone replacement therapy (HRT) on the quality and amount of tear, intraocular pressure (IOP) and retrobulbar blood flow velocities. PATIENTS AND METHODS: Twenty females aged between 40 and 50 years, free of ocular and systemic diseases and planning to receive HRT, were recruited as the study group. Twenty-four healthy, age-matched, but still menstruating, women were enrolled as controls. On the first day of the study, basal and reflex Schirmer test, tear break-up time and IOP measurements (at 08.00, 12.00 and 16.00 hours) were performed in all groups. On the second day of the study, the peak systolic velocity (PSV), end diastolic velocity (EDV) and resistivity index (RI) of the ophthalmic (OA), central retinal (CRA), nasal (NSPCA) and temporal short posterior ciliary (TSPCA) arteries were determined by color Doppler imaging. The menopausal group received HRT for two months, when all measurements were repeated for the 15 females who had received HRT on a daily basis. RESULTS: The quality and amount of tear decreased (p < 0.01), IOP (p < 0.01) and RI of the CRA, TPCA and NPCA (p < 0.05) increased in postmenopausal women compared with the control group. After two months of HRT, the quality and amount of tear had increased (p < 0.001) and IOP had decreased (p < 0.001). PSV of the CRA and TSPCA had decreased (p < 0.05), as had RI in the CRA (p < 0.001), NSPCA and TSPCA (p < 0.05). CONCLUSIONS: The authors conclude that age-induced changes on quality and amount of tear, IOP and retrobulbar blood flow are intensified by the menopause and that it may be possible to decrease the menopausal effects on these parameters by HRT.
Dr. O. Altintas, Department of Ophthalmology, School of Medicine, University of Kocaeli, Izmit, Turkey. Ozgulaltintas@yahoo.com
Classification:
9.2.2 Other risk factors for glaucoma (Part of: 9 Clinical forms of glaucomas > 9.2 Primary open angle glaucomas)
9.4.15 Glaucoma in relation to systemic disease (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders)
