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Abstract #10444 Published in IGR 6-1
Factors associated with long-term progression or stability in exfoliation glaucoma
Konstas AG; Hollo G; Astakhov YS; Teus MA; Akopov EL; Jenkins JN; Stewart WCArchives of Ophthalmology 2004; 122: 29-33
OBJECTIVE: To evaluate the effect of intraocular pressure (IOP) reduction on long-term progression or stability in patients with exfoliation glaucoma. DESIGN: Multicenter (Greece, Spain, Russia, and Hungary), retrospective analysis. METHODS: Medical record analysis of 167 patients with at least five years of follow-up, who were stable (n = 85) or whose condition had progressed (n = 82) after the start of the follow-up period. RESULTS: The mean ± SD IOP was 18.1 ± 2.6 mmHg in the stable group and 20.1 ± 4.3 mmHg in the progressed group (p < 0.001). The mean ± SD follow-up time was 6.1 ± 2.3 years for the stable group and 3.4 ± 1.7 years for the progressed group. The mean SD for each patient's average IOP was 2.9 mmHg for the stable group and 4.6 mmHg for the progressed group (p < 0.001). Twenty-eight percent of patients who had a mean IOP of 17 mmHg or lower, 43% of those with an IOP of 18-19 mmHg, and 70% of those with an IOP of 20 mmHg or higher progressed. Progressed patients had statistically greater optic disc damage at baseline and more medication changes and trabeculectomies during follow-up than stable patients (p < 0.05). CONCLUSIONS: This study suggests that IOP reduction helps to prevent glaucoma progression in patients with exfoliation glaucoma, although it does not guarantee the prevention or worsening of the disease.
Dr. A.G. Konstas, University Department of Ophthalmology, AHEPA Hospital, Thessaloniki, Greece
Classification:
9.4.4.1 Exfoliation syndrome (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders > 9.4.4 Glaucomas associated with disorders of the lens)
