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Abstract #104512 Published in IGR 23-2
Patients with Retinitis Pigmentosa May Have a Higher Risk of Developing Open-Angle Glaucoma
Hung MC; Hung MC; Chen YYJournal of Ophthalmology 2022; 2022: 9719095
BACKGROUND: Retinitis pigmentosa (RP) is the most common retinal hereditary dystrophy, which can lead to blindness if it progresses. Similarly, open-angle glaucoma (OAG) is a genetic disorder. The similarities in genetic variants and pathophysiology between RP and OAG have been reported. We sought to explore whether patients with RP have a significantly higher risk of OAG development. METHODS: We enrolled patients with RP into the RP group through Taiwan's National Health Insurance Research Database from 2001 to 2013; we included a comparison group of 1 : 4 age- and gender-matched individuals without RP. We performed a Cox regression analysis to estimate the crude and adjusted hazard ratios (HRs) for OAG. We adjusted the following confounders in the Cox regression model: age, gender, diabetes mellitus, hypertension, and chronic kidney disease. RESULTS: We enrolled 6,223 subjects with RP and 24,892 subjects for comparison. The mean age of the cohort was 49.0 ± 18.1 years. The RP group had significantly higher percentages of diabetes mellitus, hypertension, and hyperlipidaemia. The cumulative incidence of OAG in patients with RP was 1.57%; this was significantly higher than that in the comparison group (0.58%, < 0.0001). On univariate Cox regression analysis, the hazard of OAG development was significantly greater in the RP group than in the comparison group with an unadjusted HR of 2.86 (95% confidence interval, 2.21-3.70). The increased risk persisted after adjusting for confounders (adjusted HR = 2.86; 95% CI, 2.21-3.70). CONCLUSIONS: This nationwide population-based cohort study showed that people with RP are at a significantly greater risk of developing OAG than individuals without it.
Department of Medical Education, Taichung Veterans General Hospital, Taichung 407, Taiwan.
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