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Abstract #104558 Published in IGR 23-2
Clinical characteristics and prognostic factors of 1 166 patients with uveal melanoma
Luo JT; Yang YH; Liu YM; Li Y; Wei WBChinese Journal of Ophthalmology 2022; 58: 529-534
To analyze the clinical characteristics and survival of Chinese uveal melanoma (UM) patients. It was a retrospective case series study. Clinical data and demography characteristics of 1 166 UM patients who were diagnosed in Beijing Tongren Hospital from January 2004 to January 2020 were collected. The disease was followed up after informed consent was obtained. Kaplan-Meier plots were used to visualize survival outcomes, and the different risk groups were compared using the Log-rank test. The multivariate Cox proportional hazards model was used to select independent prognostic risk factors. A total of 1 166 individuals (598 men, 568 women) were included in this study. The average age was (47.6±12.2) years. Median follow-up time was 38 months. Treatment included episcleral brachytherapy in 881 (75.6%) patients, local tumor resection in 38 (3.2%) patients, laser therapy in 115 (9.9%) patients and primary enucleation in 119 (10.2%) patients. In 120 patients out of the 881 patients with primary brachytherapy, enucleation was performed due to an increasing tumor size or uncontrolled neovascular glaucoma. The Kaplan-Meier survival analysis showed the 5-and 10-year metastasis rates were 18.5% and 26.8%, and the melanoma-related mortality rates were 13.6% and 22.2%, respectively. The Log-rank test showed that patient age (²=5.01) and gender (²=7.19), as well as tumor grade (²=49.11), shape (²=34.73), location (²=18.60), pathological type (²=8.07), presence of subretinal fluid (²=15.71) and ciliary body involvement (²=19.72) were factors influencing patient prognoses (all <0.05). In the multivariate Cox analysis, the T2, T3, T4 tumors (compared with the T1 tumor, =4.41, 6.82, 10.49), subretinal fluid (=1.98), ciliary body involvement (=1.79), being male (=1.53) and advanced age (greater than 53 years old) (1.83) were independent risk factors for poor prognoses (all <0.05). UM occurs at a significantly earlier age and non-pigmented tumors represent smaller proportion in Chinese patients. Higher T-stage, presence of subretinal fluid, ciliary body involvement, advanced age, and being male are independent risk factors for poor outcomes.
Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Key Laboratory of Ophthalmology & Visual Sciences, Medical Artificial Intelligence Research and Verification Laboratory of the Ministry of Industry and Information Technology, Beijing 100730, China.
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