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WGA Rescources

Abstract #104562 Published in IGR 23-2

Long Term Effect of Canaloplasty on IOP and use of IOP-Lowering Medications in Patients with Open Angle Glaucoma: Canaloplasty and IOP/Medications in Open Angle Glaucoma

Ondrejka S; Körber N; Dhamdhere K
Journal of Cataract and Refractive Surgery 2022; 48: 1388-1393


PURPOSE: To assess the long-term safety and effectiveness of canaloplasty in reducing intraocular pressure (IOP) and use of IOP-lowering medications in eyes with open-angle glaucoma (OAG). SETTING: Surgical center (Augencentrum Köln, Köln, Germany). DESIGN: Retrospective study of 206 eyes from 130 patients. METHODS: Canaloplasty was performed using the VISCO360® or OMNI® surgical system as a stand-alone procedure in 22 eyes and concomitantly with cataract extraction (CE) in 185 eyes with chronic OAG insufficiently controlled or intolerant to IOP-lowering medications. The number of hypotensive medications and IOP were recorded at baseline, Day 1, Week 1, Month 1, Month 3, and every three months thereafter, with the last follow-up visit at 36±6 months post-surgery. Patients were stratified by baseline IOP (Group 1, IOP >18 mmHg; Group 2, IOP ≤18 mmHg). Treatment success in Group 1 was defined as a reduction in IOP and the use of IOP-lowering medications; Group 2 success was defined as maintenance of a lower IOP and a reduction in medication use. RESULTS: Preoperative mean IOP of both Groups was 21.1±8.8 mmHg, with an average 2.0±0.9 hypotensive medications. The primary success endpoint was met by 73% of patients, with a mean IOP reduction in Group 1 (131 eyes; 21.8 to 15.6 mmHg, p < 0.0001), and a maintenance of IOP control in Group 2 (76 eyes; 15.4 to 13.9 mmHg, p = 0.24). Medications decreased from 2.2±0.9 to 0.9±1.1 in Group 1 (P = 0.024) and from 1.8±0.8 to 0.7±1.0 in Group 2 (P = 0.003). CONCLUSIONS: Canaloplasty alone or in conjunction with CE with the VISCO360 or OMNI surgical system is a safe, tissue-sparing and effective MIGS, using a clear corneal incision in phakic or pseudophakic eyes. Canaloplasty performed with both evaluated devices achieved statistically significant, consistent and clinically meaningful reductions in IOP and use of IOP-lowering medications in adult patients with OAG. In the consistent cohort (n=42), the IOP lowering effect lasted up to 42 months, with ongoing data collection expected to describe long-term effectiveness of this intervention.

Augencentrum Köln, Köln, Germany.

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15 Miscellaneous



Issue 23-2

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