advertisement
Abstract #104707 Published in IGR 23-2
Correlations of Full-field Stimulus Threshold with Functional and Anatomical Outcome Measurements in Advanced Retinitis Pigmentosa
Ngo WK; Jenny LA; Kim AH; Kim AH; Kolesnikova M; Kolesnikova M; Greenstein VC; Tsang SHAmerican Journal of Ophthalmology 2023; 245: 155-163
PURPOSE: To compare FST threshold values to conventional functional and anatomical measures commonly used in clinical practice. DESIGN: Cross-sectional study. METHODS: Patients with retinitis pigmentosa (RP) with non-detectable electroretinogram (ERG) rod mediated responses and light-adapted 3.0 cd·s·m 30-Hz flicker (LA 3.0 flicker) amplitudes of 15mV or less were included in this study. The threshold values for blue, white and red stimuli on FST were correlated with best corrected visual acuity, LA 3.0 flicker amplitude and implicit times, length of the ellipsoid zone (EZ) band and thickness of outer nuclear layer measurements on optical coherence tomography (OCT), and the vertical and horizontal diameters of the autofluorescent ring on autofluorescence imaging. RESULTS: Forty-two eyes of 21 patients were included in the study. The mean FST thresholds were -22.5 ± 15.5 dB, -17.6 ± 11.5 dB and -12.7 ± 6.0 dB for the blue, white, and red stimuli respectively. The threshold values for the three FST stimuli were significantly correlated with selected functional and anatomical outcome measures. Specifically, they were strongly correlated with LA 3.0 flicker amplitude and EZ band length measured on OCT. Using linear regression, blue and white stimulus values on FST were found to be predictive of EZ band length (R = 0.579 and 0.491 respectively), the vertical (R = 0.694 and 0.532 respectively), and horizontal (R = 0.626 and 0.400 respectively) diameters of the hyperautofluorescent ring. CONCLUSIONS: The significant correlations between FST and other clinical outcome measures highlight its potential as an adjunct outcome measure.
Edward S. Harkness Eye Institute, Department of Ophthalmology, Columbia University Medical Center, New York, New York, USA; Jonas Children's Vision Care and Bernard & Shirlee Brown Glaucoma Laboratory, Department of Ophthalmology, Columbia University, New York, New York, USA; National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore.
Full article