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Abstract #104737 Published in IGR 23-2
Relationship Between Optical Coherence Tomography and Anterior Chamber Depth after Pupillary Dilation in Primary Angle Closure Suspects
Kao BW; Yonamine S; Zhao M; Oatts J; Yu Y; Ying GS; Xu X; Han YJournal of Glaucoma 2022; 31: 915-919
PRECIS: Anterior chamber depth change after pupillary dilation is correlated with lens vault and anterior chamber width, as observed by SS-OCT at both horizontal and vertical scans in patients with PACS and cataract. PURPOSE: To evaluate the association between anterior chamber depth (ACD) and other anterior chamber parameters after pharmacological dilation in patients with primary angle closure suspect (PACS) and cataract. PATIENTS AND METHODS: Swept-source optical coherence tomography (SS-OCT) was performed for 78 patients at baseline and 1 hour following pharmacologic dilation. Measurements were taken at 8 evenly spaced axes at 250, 500, and 750 μm from the scleral spur. Pearson's correlation coefficient (ρ) was used to evaluate the relationship between averaged ACD change and other SS-OCT parameters. Multivariable regression analyses were performed to determine parameters that predict ACD change. RESULTS: Across all 14 dimension and angle parameters, 12 parameters at the 270° axis and 10 parameters at the 0° axis yielded significant correlations with ACD change (ρ=0.24 to 0.55, P<0.05). Angle parameters were most significantly correlated to ACD change 750 µm from the scleral spur. The prediction model for ACD change after pharmacological dilation at 0° included: decreased lens vault (LV), wider anterior chamber width (ACW), and increased trabecular iris space area (TISA) (all P≤0.001). The prediction model for ACD change at 270° included: decreased LV, wider ACW, larger change in anterior chamber volume (ACV), larger baseline ACV, and smaller baseline angle opening distance (AOD) (all P≤0.03). CONCLUSIONS: LV and ACW, as measured in both vertical and horizontal scans, were found to be determinants of the ACD change after pharmacologic pupillary dilation. Examination of these parameters may help identify patients at higher risk of developing angle-closure disease.
Department of Ophthalmology, University of California, San Francisco, San Francisco, CA.
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