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Abstract #104876 Published in IGR 23-2
The Effect of Amniotic Membrane Transplantation on Trabeculectomy in Patients with Pseudoexfoliation Glaucoma
Kim H; Moon S; Kim J; Lee JJournal of Ophthalmology 2022; 2022: 9355206
PURPOSE: The aim is to evaluate the effect of amniotic membrane transplantation (AMT) on trabeculectomy with mitomycin C in patients with pseudoexfoliation glaucoma (PXG). METHODS: This retrospective cohort study included 85 eyes of PXG who underwent trabeculectomy with or without AMT (52/33 eyes in the AMT/control group). Surgical success was defined by these criteria: (1) intraocular pressure (IOP) ≤18 mmHg and IOP reduction ≥20% and (2) IOP ≤15 mmHg and IOP reduction ≥25%. Criteria A and B defined complete success rates as patients who met these criteria without medication, respectively. Criteria C and D defined qualified success rates as patients who met these criteria with medication, respectively. Cumulative probabilities of success were compared using the Kaplan-Meier survival analysis. Cox proportional hazard models were used to evaluate the influence of AMT on surgical success accounting for confounding variables. RESULTS: For the AMT group, compared with the control group, the complete success rates at 12 months for criterion A were 86.5% and 63.6%, respectively ( = 0.017) and for criterion B, 86.4% and 63.6% ( = 0.005). The qualified success rates at 12 months for criterion C were 92.1% and 75.1%, respectively ( = 0.047) and for criterion D, 92.1% and 72.1% ( = 0.021). On multivariable Cox regression analyses, AMT was associated with a lower failure rate on criteria A, B, and D (all ≤ 0.047). Incidence of avascular bleb was higher in the control group than in the AMT group (7 vs 0 eyes; = 0.004). CONCLUSIONS: In patients with PXG, trabeculectomy with AMT was associated with higher success rates and a lower incidence of avascular bleb compared with conventional trabeculectomy. This retrospective cohort study was registered at the Clinical Trial Registry of Korea (https://cris.nih.go.kr/cris/index/index.do, KCT0007228).
Department of Ophthalmology, Pusan National University College of Medicine, Busan, Republic of Korea.
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