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Abstract #10494 Published in IGR 6-1
The aqueous levels of TGF-β2 in patients with glaucoma
Ozcan AA; Ozdemir N; Canataroglu AInternational Ophthalmology 2004; 25: 19-22
PURPOSE: To evaluate the aqueous levels of transforming growth factor beta-2 (TGF-β2) in open angle glaucoma patients. METHODS: The aqueous levels of active TGF-β2 were detected in 17 eyes of 17 patients using ELISA method. The control group consisted of six cataract-extracted patients. RESULTS: Mean age of the patients (60.8 ± 8.8 years), was similar to that of the controls (57.5 ± 9.8 years) (p = 0.516). Levels of TGF-β2 in aqueous samples of glaucoma patients (2.74 ± 1.23 ng/ml) were found to be elevated when compared to those of controls (1.67 ± 0.32 ng/ml) (p = 0.020). CONCLUSIONS: The authors suggest that the elevated levels of TGF-β2 in the aqueous of glaucoma patients could play a role in the pathogenesis of glaucoma.
Dr. A.A. Ozcan, Cukurova University, Medical Faculty, Department of Ophthalmology, 01330 Balcall, Adana, Turkey
Classification:
2.6.3 Compostion (Part of: 2 Anatomical structures in glaucoma > 2.6 Aqueous humor dynamics)