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Abstract #104954 Published in IGR 23-2
Increased Risk of Ocular Hypertension in Patients with Cushing's Disease
Yichen M; Chen Z; Ma Z; Ye H; Zhang Z; Wang Y; Yang H; Lu Z; Wang Z; Qiao N; Xiao Y; Zhao YJournal of Glaucoma 2022; 31: 941-946
INTRODUCTION: Systemic steroid use is a significant risk factor for increased intraocular pressure (IOP). The incidence of ocular hypertension may rise to 30-40% of the general population due to topical or systemic glucocorticoid usage. However, the incidence of ocular hypertension in endogenous hypercortisolemia, as well as the ophthalmological outcomes after endocrine remission due to a surgical resection, remain unknown. MATERIAL AND METHODS: The IOP, visual field, and peripapillary retinal nerve fiber layer thickness were documented in all patients with Cushing's disease (CD) admitted to a tertiary pituitary center for surgery from January to July 2019. Patients with acromegaly and patients with nonfunctioning pituitary adenoma (NFPA) during the same study period served as controls. We calculated the odds ratio, identified the risk factors of developing ocular hypertension, and presented postoperative trends of the IOP. RESULTS: A total of 52 patients (38.4±12.4 y old) with CD were included. The IOP was higher in patients with CD (left 19.4±5.4 mmHg and right 20.0±7.1 mmHg) than in patients with acromegaly (left 17.5±2.3 mmHg and right 18.6±7.0 mmHg, P=0.033) and patients with NFPA (left 17.8±2.6 mmHg and right 17.4±2.4 mmHg, P=0.005). A total of 21 eyes (20.2%) in patients with CD were diagnosed with ocular hypertension compared to four eyes (4.7%) in the acromegaly group and four eyes (4.5%) in the NFPA group. The odds ratio of developing ocular hypertension in patients with CD was 5.1 (95% CI, 1.3-25.1, P=0.029) and 6.6 (95% CI, 1.8-30.3, P=0.007) when compared with the two control groups. Among patients with CD, those with a higher urine free cortisol were more likely to develop ocular hypertension (OR 19.4, 95% CI 1.7-72.6). The IOP decreased at one-month after surgery in patients with CD, and the change was sustained for three-months after surgery. CONCLUSIONS: An increased risk of ocular hypertension was seen in CD and suggests that endogenous hypercortisolemia should be considered as part of the glaucoma assessment. This result warrants the discretion of both ophthalmologists and neuroendocrinologists.
Department of Ophthalmology, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China.
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