advertisement
Abstract #104969 Published in IGR 23-2
Association of ultra-short-term Intraocular Pressure Fluctuation with Disease Progression in Primary Angle Closure Glaucoma: The CUPAL Study
Tan S; Yu M; Baig N; Chan PP; Tang FY; Cheung CY; Tham CCYJournal of Glaucoma 2022; 31: 874-880
PURPOSE: To identify the most sensitive period for detecting significant ultra-short-term intraocular pressure (IOP) fluctuation associated with disease progression in primary angle closure glaucoma (PACG). METHODS: PACG eyes, which had been followed up for over 2 years under the CUHK PACG Longitudinal (CUPAL) Study, were recruited. Eyes with or without functional or structural glaucomatous progression were classified into 'progressive' or 'stable' groups based on serial visual field (VF) and retinal nerve fiber layer (RNFL) thickness documentations, respectively. Ultra-short-term IOP fluctuations were recorded by Sensimed Triggerfish® sensors (Sensimed AG, Lausanne, Switzerland) with 288 readings over 30 seconds, at 5-minute intervals, over a 24-hour period. In each of seven activity-related one-hour periods during the examining day, the mean value of the amplitude-frequency profiles of the signal fluctuations in twelve 30-second intervals was calculated by semi-variogram / semi-variance. The 'progressive' and 'stable' groups were compared by permutation tests on functional t-statistics. RESULTS: Among the 25 recruited PACG eyes, 16 eyes were classified as RNFL 'progressive' group (the mean rate of change in global RNFL thickness: -0.199 ±0.128 mm/month). Higher signal fluctuations, in terms of amplitude-frequency, were found during the first 1-hour period of sleeping in the RNFL 'progressive' group, compared to the RNFL 'stable' group (P=0.028). CONCLUSIONS: Between RNFL 'progressive' and 'stable' PACG eyes, significant differences in ultra-short-term IOP fluctuation at the 1-hour period after falling asleep were identified. The first hour of sleeping may be the most sensitive period for detecting significant ultra-short-term IOP fluctuation in PACG eyes.
Full article