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Abstract #105011 Published in IGR 23-2
Age-related Changes in Intraocular Pressure: Japan Ningen Dock Study
Terauchi R; Wada T; Fukai K; Fukai K; Tatemichi M; Ogawa S; Noro T; Ito K; Kato T; Kato K; Nakano TJournal of Glaucoma 2022; 31: 927-934
PRCIS: The analysis of Intraocular pressure by age using mega database showed a consistent age-related intraocular pressure decrease with a drastic downward trend in the participants under 30 and over 70 years. PURPOSE: To clarify the association between age and intraocular pressure (IOP), IOP value by age was assessed using large IOP database. PATIENTS AND METHODS: This cross-sectional study was conducted among 103 health checkup institutions registered to Japan Society of Ningen Dock, and included participants who underwent annual health checkups between April 2014 and March 2015. The inclusion criteria were: complete data for IOP in both eyes, body mass index, waist circumference, blood pressure, hemoglobin A1c, and a self-administered health questionnaire. A total of 655,818 participants were enrolled. The mean age was 51.5±10.5 years (range, 20-96 y), and 40.1% were women. IOP was measured using a non-contact tonometer. Multiple linear regression analysis was conducted to explore factors associated with IOP, including age, as well as analyses stratified by age group: <40, 40-69, and ≥70 years. RESULTS: A consistent negative association between IOP and age [β=-0.353 (95% confidence interval: -0.360 to -0.346)] was observed. In the age groups of <40 and ≥70 years, the age-related IOP decline was more pronounced (β=-0.502 [95% confidence interval: -0.566 to -0.439]; β=-0.674 [95% confidence interval: -0.753 to -0.595]), with it being 14.21±2.95 and 11.18±2.52 mmHg in the 20-24 and 90-96 year age groups, respectively. The middle-aged (aged 40-69 y) population showed gradual decline [β=-0.313 (95% confidence interval: -0.323 to -0.303)]. CONCLUSION: Age was strongly and negatively associated with IOP. The magnitude of IOP decline across lifespans was approximately 3 mmHg. Age-related decreases in IOP were non-linear and phasic.
Department of Ophthalmology, The Jikei University School of Medicine, Tokyo, 105-8461, Japan.
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