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Abstract #105240 Published in IGR 23-3
On the protective role of the blood vessels in glaucomatous damage: A transversal study
Cánovas-Serrano Y; Vallés-San-Leandro L; Rodríguez-Izquierdo MÁ; López-Serrano R; Lajara-Blesa JJournal of optometry 2023; 16: 81-87
PURPOSE: To corroborate whether vessels on the surface of the optic nerve head can provide protection against the loss of underlying axons in subjects with manifest glaucoma. METHODS: In this pilot study, thirty-six glaucomatous eyes with a perimetric defect in the Bjerrum area were included. The retinal nerve fiber layer (RNFL) thickness was measured in each of the sectors of the clock-hour map obtained by Cirrus HD-OCT considering the presence or absence of blood vessels. These sectors were related with their corresponding areas of the retina examined in the visual field using a mathematical model of the retina introduced by Jansonius, in order to determine the values of threshold sensitivity in those areas in the presence or absence of vessels. RESULTS: We corroborated the protective role of the blood vessel for peripapillary RNFL thickness of clock-hour 12 despite obtaining a p-value (p = 0.023; w = 228.5) close to the acceptance zone (p ≥ 0.05). The mean ± standard deviation with vessel and without vessel were 70.95 ± 24.35 and 88.46 ± 23.96, respectively. No differences were found between the mean values of threshold sensitivity to the presence or absence of blood vessels in each of the sectors considered. CONCLUSIONS: Our findings do not allow us to affirm that there is an association between the presence of a vessel and protection against glaucomatous damage in subjects with an advanced manifestation of the disease. In the future, more extensive studies are needed to study this relationship in subjects with early glaucoma.
Health Sciences PhD program, Catholic University of Murcia (UCAM), Campus de los Jerónimos n°135, Guadalupe 30107, Murcia, Spain. Electronic address: ycanovas@alu.ucam.edu.
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