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Abstract #10567 Published in IGR 6-2
Diabetes mellitus as a risk factor for primary open-angle glaucoma: A meta-analysis
Bonovas S; Peponis V; Filioussi KDiabetic Medicine 2004; 21: 609-614
AIM: The association of diabetes mellitus with primary open-angle glaucoma has been controversial. The study aimed to examine the strength of this association through a detailed meta-analysis of studies published in peer-reviewed journals. METHODS: A comprehensive search for articles published through 2002 was performed and data were abstracted. Prior to meta-analysis, all studies were evaluated for publication bias and heterogeneity. Pooled odds ratio (OR) was calculated using the random and the fixed-effects model. RESULTS: Twelve studies published between 1987 and 2001 were included (five case-control studies and seven cross-sectional studies). Significant heterogeneity among the studies was detected (P = 0.023). No evidence of publication bias was found (P = 0.37). The association of diabetes mellitus with primary open-angle glaucoma was statistically significant assuming either a random effects [OR = 1.50, 95% confidence interval (CI) 1.16, 1.93], or a fixed-effects model (OR = 1.27, 95% CI 1.10,1.45). CONCLUSIONS:: Our meta-analysis results suggest that diabetic patients are at significantly increased risk of developing primary open-angle glaucoma. Clinicians should be aware of this possibility.
Department of General Practice, General Hospital of Athens G. Gennimatas, Athens, Greece. sbonovas@med.uoa.gr
Classification:
9.2.2 Other risk factors for glaucoma (Part of: 9 Clinical forms of glaucomas > 9.2 Primary open angle glaucomas)
9.4.15 Glaucoma in relation to systemic disease (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders)
