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Abstract #10577 Published in IGR 6-2
In vitro inhibition effects of some new sulfonamide inhibitors on human carbonic anhydrase I and II
Cakir U; Ugras HI; Ozensoy O; Sinan S; Arslan OJournal of Enzyme Inhibition and Medicinal Chemistry 2004; 19: 257-261
A new series of aromatic and heterocyclic sulfonamides, including six new derivatives, 2-(3-cyclohexene-1-carbamido)-1,3,4-thiadiazole-5-sulfonamide (CCTS), 4-(3-cyclohexene-1-carbamido) methyl-benzenesulfonamide (CCBS), 2-(9-octadecenoylamido)-1,3,4-thiadiazole-5-sulfonamide (ODTS), 2-(4,7,10-trioxa-tetradecanoylamido)-1,3,4-thiadiazole-5-sulfonamide (TDTS), 2-(coumarine-3-carbamido)-1,3,4-thiadiazole-5-sulfonamide (COTS) and 2-(8-methoxycoumarine-3-carbamido)-1,3,4-thiadiazole-5-sulfonamide (MCTS), has been investigated. These sulfonamides were assayed for inhibition of human carbonic anhydrase I (hCA-I) and human carbonic anhydrase II (hCA-II) which were purified by affinity chromatography.
O. Arslan, Balikesir Univ. Science/Art Faculty, Department of Chemistry, 10100 Balikesir
Classification:
11.5 Carbonic anhydrase inhibitors (Part of: 11 Medical treatment)
