advertisement
Abstract #105815 Published in IGR 23-3
Smart soft contact lenses for continuous 24-hour monitoring of intraocular pressure in glaucoma care
Zhang J; Kim K; Kim HJ; Meyer D; Park W; Lee SA; Dai Y; Kim B; Moon H; Shah JV; Harris KE; Collar B; Liu K; Irazoqui P; Lee H; Park SA; Kollbaum PS; Boudouris BW; Lee CHNature communications 2022; 13: 5518
Continuous monitoring of intraocular pressure, particularly during sleep, remains a grand challenge in glaucoma care. Here we introduce a class of smart soft contact lenses, enabling the continuous 24-hour monitoring of intraocular pressure, even during sleep. Uniquely, the smart soft contact lenses are built upon various commercial brands of soft contact lenses without altering their intrinsic properties such as lens power, biocompatibility, softness, transparency, wettability, oxygen transmissibility, and overnight wearability. We show that the smart soft contact lenses can seamlessly fit across different corneal curvatures and thicknesses in human eyes and therefore accurately measure absolute intraocular pressure under ambulatory conditions. We perform a comprehensive set of in vivo evaluations in rabbit, dog, and human eyes from normal to hypertension to confirm the superior measurement accuracy, within-subject repeatability, and user comfort of the smart soft contact lenses beyond current wearable ocular tonometers. We envision that the smart soft contact lenses will be effective in glaucoma care.
Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA.
Full article