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Abstract #105923 Published in IGR 23-3
Characterization of the human iridocorneal angle using a custom design goniolens with OCT gonioscopy
Carmichael-Martins A; Gast TJ; Burns SA; Walker BR; King BJBiomedical optics express 2022; 13: 4652-4667
Intraocular pressure (IOP) is the only modifiable risk factor for glaucoma progression, and many treatments target the trabecular meshwork (TM). Imaging this region is challenging due to optical limitations of imaging through the cornea at high angles. We propose a gonioscopic OCT approach using a custom goniolens and a commercially available OCT device to improve imaging of the TM, Schlemm's canal (SC) and adjacent structures within the iridocorneal angle (ICA). The goniolens is modified with a plano-convex focusing lens and placed on the eye optically mated with goniogel and aided by a 3D adjustable mount. Gonioscopic OCT volume scans are acquired to image SC. Transverse images allowed measurements of SC over a 45° section of the ICA for the first time and revealed locations of SC narrowing. The band of extracanalicular limbal lamina and corneoscleral bands were imaged in most subjects and these bands were confirmed using exterior OCT imaging. The polarization dependence of the visibility of these structures is studied by polarization rotation the OCT beam with a half-wave plate, allowing increased contrast of SC. Gonioscopic OCT has successfully been used to image the human ICA in 3D This approach provides more detailed characterization of the TM and SC, enhancing their contrast against their birefringent backgrounds.
School of Optometry, Indiana University, Bloomington, Indiana 47401, USA.
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