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Abstract #10612 Published in IGR 6-2
Effect of intraocular pressure and arterial blood pressure variations on glaucoma progression
Denis PJournal Français d'Ophtalmologie 2004; 27, Hors série 2: 2S27-2S32
PURPOSE: The purpose of this paper is to collect data describing the implication of intraocular pressure (IOP) and arterial blood pressure in the progression of glaucoma. METHOD: The literature selection for this article was based on MEDLINE searches covering the last 20 years and relevant articles. Topics covered were ambulatory blood pressure monitoring, IOP fluctuations, arterial hypotension, and glaucoma. RESULTS: Hypoperfusion of the optic nerve head is among the significant factors relating to glaucoma damage. The physiological decrease in nocturnal blood pressure is more pronounced in some glaucoma patients, particularly in those presenting normal pressure glaucoma or with progressive visual field loss. Normal human subjects have a circadian variation in their IOP and these fluctuations are related to the sleep-wake cycle. In glaucoma patients, unappreciated IOP fluctuations may explain many cases of glaucoma progression. DISCUSSION AND CONCLUSION: Eyes with advanced glaucomatous optic neuropathy were associated with more marked alterations in the optic nerve vascular supply circulation than eyes with less nerve damage. Numerous findings suggest that circadian IOP variations and arterial blood pressure may play a role in the progression of glaucoma. LA: French
Service d'Ophtalmologie, Pavillon C, Hopital Edouard Herriot, 5, Place d'Arsonval, 69437 Lyon cedex 03, France
Classification:
6.1 Intraocular pressure measurement; factors affecting IOP (Part of: 6 Clinical examination methods)
6.11 Bloodflow measurements (Part of: 6 Clinical examination methods)
9.2.2 Other risk factors for glaucoma (Part of: 9 Clinical forms of glaucomas > 9.2 Primary open angle glaucomas)
