advertisement
Abstract #106302 Published in IGR 23-3
Indoor air pollution and human ocular diseases: Associated contaminants and underlying pathological mechanisms
Yang DL; Zhang ZN; Liu H; Yang ZY; Liu MM; Zheng QX; Chen W; Xiang PChemosphere 2022; 311: 137037
People spend a long time indoors, especially young children. The risk of indoor pollution on human health is one of the current hotspots in environmental and public health. The human ocular surface is highly susceptible to indoor environment quality. Epidemiological data have linked human ophthalmological disorders with exposure to indoor pollution. In this review, we summarized the adverse impacts of indoor pollution on the human ocular surface. Several studies demonstrated that indoor contaminants including particulate matter, volatile/semi-volatile organic compounds, heavy metals, and fuel combustion and cigarette smoke exposure were associated with the incidence of human dry eye, conjunctivitis, glaucoma, cataracts, age-related macular degeneration, and keratitis. In addition, toxicological investigations revealed that indoor pollution-induced induced chronic inflammation, oxidative damage, and disruption of tight junctions are the main underlying pathological mechanisms for ocular surface diseases. Taken together, this review may expand the understanding of pollution-induced eye disorder and highlight the importance of reducing associated contaminants to decrease their detrimental effects on human eyes.
Yunnan Province Innovative Research Team of Environmental Pollution, Food Safety, and Human Health, School of Ecology and Environment, Southwest Forestry University, Kunming, 650224, China.
Full article