advertisement
Abstract #10685 Published in IGR 6-2
Addition of topical bunazosin to latanoprost in multiple medical treatment for glaucoma
Iwakiri R; Kobayashi H; Kobayashi K; Okinami SJapanese Journal of Clinical Ophthalmology 2004; 58: 359-362
PURPOSE: To evaluate the ocular hypotensive effect of bunazosin hydrhochloride 0.01% added to multiple drug therapy including latanoprost 0.005%. Cases and METHOD: A total of 50 eyes of 50 patients with primary open-angle glaucoma were enrolled in the prospective study. They had been receiving timolol 0.5%, latanoprost 0.005% and dorzolamide 1% for at least 3 months. Randomly selected 25 eyes were additionally given bunazosin 0.01%, and the other 25 eyes served as control. They were followed up for 3 months. Findings: Baseline intraocular pressure (IOP) averaged 22.4 ± 1.8 mmHg in bunazosin group and 22.2 ± 2.0 mmHg in control group. IOP in bunazosin group decreased significantly by 1.4 ± 2.1 mmHg (p = 0.0046) after 4 weeks and by 2.0 ± 1.7 mmHg (p = 0.0008) after 12 weeks. IOP after 12 weeks also decreased significantly from IOP after 2 weeks (p = 0.0344). IOP in the control group showed no significant differences from the baseline throughout. CONCLUSION: Additional bunazosin induced significant IOP reductions after 4 to 12 weeks. Since the hypotensive effect was small after 2 weeks, more than 4 weeks are necessary to evaluate the full effect of additional bunazosin. LA: Japanese
H. Kobayashi, Department of Ophthalmology, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga 849-8501
Classification:
11.4 Prostaglandins (Part of: 11 Medical treatment)
