advertisement
Abstract #106904 Published in IGR 23-3
Early Detection of Primary Open-Angle, Angle-closure, and Normal-tension Glaucoma in an Asian Population Using Optical Coherence Tomography
Wu CW; Chang YC; Chen HYJournal of Glaucoma 2023; 32: 195-203
PRCIS: SD-OCT facilitates early glaucoma detection in the Chinese population in Taiwan. The best parameters for POAG, PACG, NTG, and GS detection are temporal inferior BMO-MRW, inner temporal mGCL, temporal superior cpRNFL, and mean global BMO-MRW, respectively. PURPOSE: We investigated the diagnostic capability of spectral-domain optical coherence tomography (SD-OCT) for different types of early glaucoma among the Chinese population in Taiwan. METHODS: One eye each was assessed from 113 individuals with healthy eyes, 125 individuals with suspected glaucoma (GS), and 156 patients with early glaucoma (primary open-angle glaucoma [POAG], 87; primary angle-closure glaucoma [PACG], 50; and normal-tension glaucoma [NTG], 19). Circumpapillary (cp) retinal nerve fiber layer (RNFL) thickness (global and sectoral); Bruch's membrane opening-minimum rim width (BMO-MRW); and macular parameters, including the macular RNFL (mRNFL), macular ganglion cell layer (mGCL), and macular inner plexiform layer (mIPL), were assessed using SD-OCT. The areas under receiver operator characteristic curves (AUCs) were calculated to evaluate the diagnostic capacity of the parameters to differentiate between healthy and early glaucomatous eyes. RESULTS: The parameters most suitable for detecting early POAG, PACG, NTG and GS were temporal inferior BMO-MRW (AUC, 0.847), inner temporal mGCL (AUC, 0.770), temporal superior cpRNFL (AUC, 0.861) and mean global BMO-MRW (AUC, 0.768), respectively. Among the macular parameters, mGCL exhibited the highest diagnostic capacity. The diagnostic capacity of mGCL was lower than that of cpRNFL and BMO-MRW for POAG and NTG but not PACG. After adjusting for confounding variables in multivariable analysis, the AUC was determined to be 0.935 for POAG and 0.787 for GS. CONCLUSION: SD-OCT facilitates the detection of early POAG, PACG and NTG. Using a combination of cpRNFL, BMO-MRW and macular parameters may enhance their diagnostic capacities. Further studies are necessary to validate these findings.
Full article
