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Abstract #106906 Published in IGR 23-3
Minimum Rim Width and Peripapillary Retinal Nerve Fiber Layer Thickness for Diagnosing Early to Moderate Glaucoma
Zangalli CS; Jammal AA; Reis ASC; Ayub G; Diniz-Filho A; Paranhos A; Paula JS; Costa VPJournal of Glaucoma 2023; 32: 526-532
PRCIS: In a cross-sectional study from a Brazilian multiracial population, minimum rim width and peripapillary retinal nerve fiber layer thickness measurements from OCT showed comparable diagnostic performance in discriminating early to moderate glaucoma from healthy eyes. PURPOSE: To compare the ability of minimum rim width (MRW) and peripapillary retinal nerve fiber layer thickness (RNFLT) measurements in discriminating early to moderate glaucoma from healthy eyes in a Brazilian population. METHODS: 155 healthy controls and 118 patients with mild to moderate glaucoma (MD >-12 dB) underwent MRW and RNFLT measurements with optical coherence tomography (OCT). Only one eye per patient was included in the analysis. A receiver operating characteristic (ROC) regression model was used to evaluate the diagnostic accuracy of MRW and RNFLT, while adjusting for age and Bruch's membrane opening (BMO) area. Sensitivities at fixed specificities of 95% were calculated for each parameter. RESULTS: Global RNFLT and MRW showed comparable AUCs (0.93 [0.91-0.96] and 0.93 [0.89-0.96], respectively; P=0.973). Both parameters had similar sensitivities (75% vs. 74%, respectively; P=0.852) at a fixed specificity of 95%. The best sector for diagnosing glaucoma for both parameters was the temporal inferior sector, which showed an AUC of 0.93 (0.87-0.96) for RNFLT and 0.91 (0.86-0.95) for MRW (P=0.320). The temporal inferior sector showed similar sensitivities for RNFLT and MRW measurements (83% vs. 77%, respectively) at a fixed specificity of 95% (P=0.230). CONCLUSION: MRW and RNFLT measurements showed comparable diagnostic performance in discriminating early to moderate glaucoma from healthy eyes in a Brazilian multiracial population.
Universidade Estadual de Campinas, Campinas, Brazil.
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