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Abstract #106909 Published in IGR 23-3
Risk Factors Associated with a Large Vertical Cup-to-Disc Ratio: Korean National Health and Nutritional Examination Survey
Lee MH; Kim HK; Kim SSJournal of Glaucoma 2023; 32: 221-226
PRECIS: Higher intraocular pressure, higher systolic blood pressure, and higher serum aspartate transaminase to alanine aminotransaminase level were risk factors associated with large vertical cup-to-disc ratio. PURPOSE: To identify risk factors for a large vertical cup-to-disc ratio using data from the Korea National Health and Nutritional Examination Survey (2008-2012). METHODS: Out of the total 29,322 participants aged 20 or older who participated in Korea National Health and Nutrition Survey (KHANES) from the year 2008 to 2012, this study was conducted on 21,780 participants excluding 1,449 of them without fundus photographs and 6,093 of them with missing values. To identify the risk factors associated with a large vertical cup-to-disc ratio (vCDR), the participants were divided into two groups: ≥0.6 and <0.6. RESULTS: Of the 21,780 subjects, 2,357 of them had a vCDR ≥0.6 and 19,423 had a vCDR <0.6. There were significant differences in age, sex, and educational levels between the two groups. After adjusting age, sex, education level, and survey year by propensity score matching, in the group having vCDR ≥0.6, intraocular pressure (IOP) was high, systolic blood pressure (SBP) was high, and serum aspartate transaminase to alanine aminotransaminase level (AST/ALT ratio) was high (P<0.001, P<0.001, and P<0.001). The results of multiple logistic regression analyses revealed that high IOP, high SBP, high myopia, and high AST/ALT ratio were risk factors for vCDR ≥0.6 (P<0.001, P=0.006, P=0.005, P<0.001). CONCLUSIONS: In this study, risk factors associated with large vCDR were analyzed. Higher IOP, higher SBP, and higher AST/ALT ratio were related to vCDR ≥0.6.
Department of Ophthalmology, Dankook University Hospital, Dankook University College of Medicine, Cheonan, South Korea.
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