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PRCIS: Hyphema development after Kahook Dual Blade excisional goniotomy was significantly associated with postoperative day 1 IOP ≤12 mmHg, male gender, and narrow iridocorneal angles, but not with continuation of anticoagulation or antiplatelet therapy. PURPOSE: To identify risk factors of hyphema development after Kahook Dual Blade goniotomy combined with phacoemulsification. METHODS: 202 eyes in 145 patients who received a Kahook Dual Blade goniotomy combined with phacoemulsification between February 21, 2017 and February 18, 2020 were evaluated for preoperative factors that were predictive of postoperative hyphema. Hyphema was defined as the development of ≥1 mm layered blood in the anterior chamber. Primary outcome was the association between various preoperative factors and the development of postoperative hyphema. Binomial logistic regression was used to analyze risk factors of hyphema development while controlling for other variables. RESULTS: Hyphema occurred in 8.4% (17/202) of patients on day 1 after Kahook Dual Blade goniotomy combined with phacoemulsification. Male gender (P=0.008), angle closure glaucoma (P=0.036), and postoperative day 1 IOP ≤12 mmHg (P=0.049) were significantly correlated with hyphema development while controlling for other variables. Preoperative anticoagulation and antiplatelet therapy had no association with hyphema development (P=0.538). CONCLUSIONS: Postoperative hyphema was associated with male gender, narrow iridocorneal angles, and a postoperative day 1 IOP lower than typical episcleral venous pressure when controlling for other variables. Preoperative anticoagulation or antiplatelet therapy was not associated with developing postoperative hyphema in this study, however further investigation is needed before recommendations can be made.
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