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Abstract #106936 Published in IGR 23-3
A Prospective Observational Study on Changes in Intraocular Pressure and Iridocorneal Angle Following the Use of Escitalopram and Amitriptyline
Mandal S; Acharya R; Mallik N; Jain S; Ghosh AK; Ghosal MK; Pal AIndian journal of psychological medicine 2023; 45: 38-42
BACKGROUND: Depression has emerged as one of the prime morbidities affecting professional and personal lives worldwide. Antidepressants are one of the mainstays of management of depressive episodes. Although antidepressants are considered a safe class of drugs, the studies examining the effects of antidepressant prescription on intraocular pressure (IOP) have shown a propensity to increase IOP, but not consistently. This study aimed to compare the changes in IOP and iridocorneal angle in drug-naïve patients with depressive episodes prescribed escitalopram or amitriptyline. METHODS: Overall, 109 patients were recruited, of which 53 were prescribed amitriptyline and 56, escitalopram. A comparison of IOP and the iridocorneal angle at weeks 0, 4, and 8 was done using a two-way repeated-measures analysis of variance (two-way RM analysis of variance). RESULTS: Patients initiated on escitalopram tended to show a higher rise in the IOP (left eye-[ = 3.27; P = 0.04]; right eye [ = 2.47; P = 0.08]). No difference was found in the iridocorneal angles in any of the four quadrants across both eyes. CONCLUSIONS: Escitalopram use had an association with an increase in IOP. While initiating patients on antidepressants, clinicians should be aware of this possibility, which can lead to ocular emergencies, and obtain a proper history of ocular morbidities.
Dept. of Psychiatry, Medical College and Hospital, Kolkata, West Bengal, India.
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