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Abstract #10716 Published in IGR 6-2
Ocular hypotensive effect of brinzolamide after switching from dorzolamide
Kubota M; Hara T; Kubota S; Hashimoto T; Tsuru-TJapanese Journal of Clinical Ophthalmology 2004; 58: 301-303
PURPOSE: To compare the ocular hypotensive effect of 1% brinzolamide and dorzolamide ophthalmic solutions. Cases and METHODS: A prospective study was conducted on 30 eyes of 30 patients of primary open-angle glaucoma. The series comprised 15 males and 15 females. Their ages ranged from 32 to 87 years, average 64.2±13.3 years. All the eyes had well-controlled intraocular pressure (IOP) during the previous 6 months under treatments including dorzolamide. The 30 eyes were divided into two groups. One group switched to brinzolamide from dorzolamide. The other group continued the previous medications including dorzolamide and served as control. The average IOP level was calculated in both groups during 3 months before and after start of the study. Tonometry was also performed in both groups at one-month intervals. RESULTS: IOP during 3 months before start of the study averaged 15.6±3.6 mmHg in brinzolamide group and 15.4±2.4 mmHg in control group. There were no significant differences between the two groups regarding IOP before and after start of study. CONCLUSION: Brinzolamide and dorzolamide have equal ocular hypotensive effect. LA: Japanese
M. Kubota, Department Ophthalmology, Jichi Medical School, 3311-1 Yakushiji Minamikawachi-machi, Kawachi-gun 329-0498
Classification:
11.5.2 Topical (Part of: 11 Medical treatment > 11.5 Carbonic anhydrase inhibitors)
