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Abstract #10718 Published in IGR 6-2
Safety and efficacy of unoprostone switched from latanoprost in patients with latanoprost-induced side effects
Kuga H; Miyauchi O; Fujimoto N; Sato E; Yamamoto S; Takeda N; Yamazaki H; Watanabe Y; Amaya KJapanese Journal of Clinical Ophthalmology 2004; 58: 1187-1191
We evaluated the safety and efficacy of unoprostone switched from latanoprost. The cases comprised patients that developed eyelid pigmentation or hypertrichosis as latanoprost-induced side effects. All had either primary open-angle glaucoma or normal-tension glaucoma. The intraocular pressure (IOP) was controlled below 20 mmHg by latanoprost. Patients were followed up for 6 months or longer after switching to unoprostone. Eyelid pigmentation was present in 19 eyes by photographic evaluation. It improved in 13 eyes after switching. Eyelid pigmentation was subjectively noticed in 11 eyes. It improved in 10 eyes after switching. Hypertrichosis was present in 13 eyes by photographic evaluation. It improved in 10 eyes after switching. Hypertrichosis was subjectively noticed in 7 eyes. It improved in 5 eyes after switching. There was no significant difference in visual acuity, IOP or visual field after switching. The findings show that eyelid pigmentation and hypertrichosis may improve by switching from latanoprost to unoprostone. LA: Japanese
H. Kuga, Dept. of Ophthalmol. and Vis. Sci., Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo, Chiba 260-8670
Classification:
11.4 Prostaglandins (Part of: 11 Medical treatment)