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Abstract #107550 Published in IGR 23-4
Calcium-Signalling in Human Glaucoma Lamina Cribrosa Myofibroblasts
Irnaten M; O'brien CJInternational journal of molecular sciences 2023; 24:
Glaucoma is one of the most common causes of treatable visual impairment in the developed world, affecting approximately 64 million people worldwide, some of whom will be bilaterally blind from irreversible optic nerve damage. The optic nerve head is a key site of damage in glaucoma where there is fibrosis of the connective tissue in the lamina cribrosa (LC) extracellular matrix. As a ubiquitous second messenger, calcium (Ca) can interact with various cellular proteins to regulate multiple physiological processes and contribute to a wide range of diseases, including cancer, fibrosis, and glaucoma. Our research has shown evidence of oxidative stress, mitochondrial dysfunction, an elevated expression of Ca entry channels, Ca-dependent pumps and exchangers, and an abnormal rise in cytosolic Ca in human glaucomatous LC fibroblast cells. We have evidence that this increase is dependent on Ca entry channels located in the plasma membrane, and its release is from internal stores in the endoplasmic reticulum (ER), as well as from the mitochondria. Here, we summarize some of the molecular Ca-dependent mechanisms related to this abnormal Ca-signalling in human glaucoma LC cells, with a view toward identifying potential therapeutic targets for ongoing optic neuropathy.
Department of Ophthalmology, Mater University Hospital, Eccles Street, D07F851 Dublin, Ireland.
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