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Abstract #108086 Published in IGR 23-4
The association between obesity and glaucoma in older adults: evidence from the China Health and Retirement Longitudinal Study
Zhao X; Bo Q; Sun J; Chen J; Li T; Huang X; Zhou M; Wang J; Liu W; Sun XEpidemiology and health 2023; 0: e2023034
OBJECTIVES: This study evaluated the association between obesity and glaucoma in middle-aged and older people. A population-based retrospective cohort study was conducted using data from the China Health and Retirement Longitudinal Study. METHODS: Glaucoma was assessed via self-reports. Multivariate logistic regression analysis and a Cox proportional hazards model were used to assess the relationship between obesity and glaucoma risk. RESULTS: Older men living in urban areas who were single, smokers, and non-drinkers were found to have a significantly higher incidence of glaucoma (all P<0.05). Diabetes, hypertension, and kidney disease were also associated with higher glaucoma risk, while dyslipidemia was associated with lower risk (all P<0.05). After the model was adjusted for demographic, socio-economic, and health-related variables, obesity was significantly associated with a 10.2% decrease in glaucoma risk according to the Cox proportional hazards model (hazard ratio, 0.898; 95% CI, 0.829-0.973) and an 11.8% risk reduction in the multivariate logistic regression analysis (odds ratio, 0.882; 95% CI, 0.803-0.968). A further subgroup analysis showed that obesity was associated with a reduced risk of glaucoma in people living in rural areas, in smokers, and in those with kidney disease (all P<0.05). Obesity also reduced glaucoma risk in people with diabetes, hypertension, or dyslipidemia more than in healthy controls (all P<0.05). CONCLUSION: This cohort study suggests that obesity was associated with a reduced risk of glaucoma, especially in rural residents, smokers, and people with kidney disease. Obesity exerted a stronger protective effect in people with diabetes, hypertension, or dyslipidemia than in healthy people.
Shanghai General Hospital, Shanghai, China.
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