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Abstract #108226 Published in IGR 23-4
Causal Association between Iritis or Uveitis and Glaucoma: A Two-Sample Mendelian Randomisation Study
Seo JH; Lee YGenes 2023; 14:
Recent studies have suggested an association between iritis or uveitis and glaucoma. This study investigated the causal relationship between glaucoma and iritis and uveitis as exposures in a multi-ethnic population. Single-nucleotide polymorphisms associated with exposures to iritis and uveitis from the genome-wide association study (GWAS) data of Biobank Japan (BBJ) and the meta-analysis data from BBJ and UK Biobank (UKB) were used as instrumental variables (IVs). The GWAS dataset for glaucoma was extracted from the meta-analysis data ( = 240,302) of Genetic Epidemiology Research in Adult Health and Aging and UKB. The casual estimates were assessed with a two-sample Mendelian randomisation (MR) test using the inverse-variance-weighted (IVW) method, weighted median method, MR-Egger method, and MR-Pleiotropy Residual Sum and Outlier test. The IVW method revealed a significant causal association between iritis and glaucoma using IVs ( < 5.0 × 10-8) from the East Asian population ( = 2) (odds ratio [OR] = 1.01, = 0.017), a significant association between iritis exposures ( < 5.0 × 10-8) in the multi-ethnic population ( = 11) (OR = 1.04, = 0.001), and a significant causal association between uveitis exposures ( = 10 with < 5.0 × 10-8) and glaucoma in the multi-ethnic population (OR = 1.04, = 0.001). Iritis and uveitis had causal effects on glaucoma risk based on IVs from the multi-ethnic population. These findings imply that the current classifications of uveitic glaucoma and open-angle glaucoma overlap, indicating the need for further investigating these complex relationships.
Veterans Medical Research Institute, Veterans Health Service Medical Center, Seoul 05368, Republic of Korea.
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