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Abstract #108229 Published in IGR 23-4
The Role of Citicoline and Coenzyme Q10 in Retinal Pathology
García-López C; García-López V; Matamoros JA; Fernández-Albarral JA; Salobrar-García E; de Hoz R; López-Cuenca I; Sánchez-Puebla L; Ramírez JM; Ramírez AI; Salazar JJInternational journal of molecular sciences 2023; 24:
Ocular neurodegenerative diseases such as glaucoma, diabetic retinopathy, and age-related macular degeneration are common retinal diseases responsible for most of the blindness causes in the working-age and elderly populations in developed countries. Many of the current treatments used in these pathologies fail to stop or slow the progression of the disease. Therefore, other types of treatments with neuroprotective characteristics may be necessary to allow a more satisfactory management of the disease. Citicoline and coenzyme Q10 are molecules that have neuroprotective, antioxidant, and anti-inflammatory properties, and their use could have a beneficial effect in ocular neurodegenerative pathologies. This review provides a compilation, mainly from the last 10 years, of the main studies that have been published on the use of these drugs in these neurodegenerative diseases of the retina, analyzing the usefulness of these drugs in these pathologies.
Instituto de Investigaciones Oftalmológicas Ramón Castroviejo, Grupo UCM 920105, IdISSC, Universidad Complutense de Madrid, 28040 Madrid, Spain.
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