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Abstract #108396 Published in IGR 23-4
The regulatory role of microRNAs in common eye diseases: A brief review
Benavides-Aguilar JA; Morales-Rodríguez JI; Ambriz-González H; Ruiz-Manriquez LM; Banerjee A; Pathak S; Duttaroy AK; Paul SFrontiers in genetics 2023; 14: 1152110
MicroRNAs (miRNAs) are highly conserved, small non-coding RNA molecules (∼21 nucleotides) that regulate numerous biological processes, including developmental timing, hematopoiesis, organogenesis, apoptosis, cell differentiation, and proliferation either by mRNA degradation or translation repression. Since eye physiology requires a perfect orchestration of complex regulatory networks, an altered expression of key regulatory molecules such as miRNAs potentially leads to numerous eye disorders. In recent years, comprehensive progress has been made in demonstrating the precise roles of miRNAs, emphasizing their potential use in diagnostic and therapeutic purposes of chronic human diseases. Thus, this review explicitly illustrates the regulatory roles of miRNAs in four common eye disorders, such as cataract, glaucoma, macular degeneration, and uveitis, and their application in disease management.
Tecnológico de Monterrey, School of Engineering and Sciences, Queretaro, Mexico.
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