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Abstract #108477 Published in IGR 23-4
Optic Disc Measurements in Children by Optical Coherence Tomography
Hashemi H; Khabazkhoob M; Heydarian S; Emamian MH; Fotouhi AJournal of Glaucoma 2023; 32: 361-368
PRCIS: This study showed the distribution of optic disc indices in a population-based sample of Iranian children in detail. Refractive errors and biometric components are among the ocular factors that are related to these indices. PURPOSE: To determine the normative value of optic nerve indices in children and their association with ocular and demographic factors. METHODS: A cross-sectional study was conducted in 2018. Biometry was done using the Allegro Biograph, and macular indices were measured by OCT imaging. RESULTS: After applying the exclusion criteria, 9051 eyes of 4784 children were analyzed. The mean±SD and 95% confidence intervals (in parentheses) of vertical cup-to-disc ratio, average cup-to-disc ratio, rim area, disc area, and cup volume were 0.45±0.15(0.45-0.46) mm, 0.43±0.14 (0.42-0.43) mm, 1.46±0.25 (1.45-1.47) mm 2 , 1.92±0.35 (1.91-1.93) mm 2 , and 0.14±0.14 (0.14-0.15) mm 3 , respectively. Vertical cup-to-disc ratio and average cup-to-disc ratio had a positive association with intraocular pressure (IOP) (both βs=0.003), and a negative association with retinal nerve fiber layer thickness (both βs=-0.001), central corneal thickness (CCT) (both βs=-0.001), anterior chamber depth (β=-0.025 and β=-0.027, respectively), lens thickness (β=-0.034 and β=-0.032, respectively), and mean keratometry (MK) (both βs=-0.015). The average cup-to-disc ratio had a positive association with height (β=0.001). Rim area had a negative association with increased age (β=-0.008), axial length (β=-0.065), IOP (β=-0.009), and MK (β=-0.014) and a positive association with macular volume (β=0.021), retinal nerve fiber layer thickness (β=0.004), and CCT (β=0.001). Disc area had a positive association with macular volume (β=0.031) and a negative association with female sex (β=-0.037), axial length (β=-0.087), anterior chamber depth (β=-0.112), lens thickness (β=-0.059), and MK (β=-0.048). The results of generalized estimating equations showed that cup volume was smaller in girls (β=-0.009), and had a positive association with height (β=0.001), IOP (β=0.003) and negative association with CCT (β=-0.0001) and MK (β=-0.012). CONCLUSION: The results provided the normative values of optic disc indices in children. Demographic factors, biometric components, IOP, SBP, and retinal parameters had a significant association with optic disc indices.
Noor Research Center for Ophthalmic Epidemiology, Noor Eye Hospital.
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