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Abstract #108601 Published in IGR 23-4
Effect of Lens Status on Diabetic Vitreous Hemorrhage Resolution
Zeng K; Cabral H; Ness S; Subramanian M; Siegel N; Chen XJournal of vitreoretinal diseases 2023; 7: 220-225
To determine the effect of lens status (pseudophakic vs phakic) on diabetic vitreous hemorrhage (VH) resolution time. Medical records were reviewed retrospectively for each case of diabetic VH until resolution, pars plana vitrectomy (PPV), or loss to follow-up. Univariate and multivariate Cox regression models were used to determine predictors of diabetic VH resolution time through estimated hazard ratios (HRs). Kaplan-Meier survival analysis compared differences in the resolution rate by lens status and other significant factors. Overall, 243 eyes were included. Pseudophakia (HR, 1.76; 95% CI, 1.07-2.90; = .03) and prior PPV (HR, 3.28; 95% CI, 1.77-6.07; < .001) were significant factors for faster resolution. Pseudophakic eyes resolved in 5.5 months (median, 25.1 weeks; 95% CI, 19.3-31.0) and phakic eyes in 10 months (median, 43.0 weeks; 95% CI, 36.0-50.0) ( = .001). More pseudophakic eyes than phakic eyes resolved without PPV (44.2% vs 24.8%) ( = .001). Eyes without prior PPV resolved in 9.5 months (median, 41.0 weeks; 95% CI, 35.7-46.3) compared with 5 months (median, 22.3 weeks; 95% CI, 9.8-34.8) in vitrectomized eyes ( < .001). Age, treatment with antivascular endothelial growth factor injections or panretinal photocoagulation, intraocular pressure medications, and glaucoma history were not significant predictors. Diabetic VH resolved almost twice as fast in pseudophakic eyes than in phakic eyes. Eyes with a history of PPV resolved 3 times quicker than those without PPV. A better understanding of VH resolution can help personalize the decision on when to proceed with PPV.
Boston University School of Medicine, Boston, MA, USA.
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