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Abstract #108645 Published in IGR 23-4
Analysis of retinal arteriolar and venular parameters in primary open angle glaucoma
Wang JP; Yu MT; Xu BL; Hua JP; Jiang LG; Wang JT; Yang WH; Tong YHInternational Journal of Ophthalmology 2023; 16: 671-679
AIM: To measure the retinal vessels of primary open angle glaucoma (POAG) patients on spectral domain optical coherence tomography (SD-OCT) with a full-width at half-maximum (FWHM) algorithm to better explore their structural changes in the pathogenesis of POAG. METHODS: In this retrospective case-control study, the right eyes of 32 patients with POAG and 30 healthy individuals were routinely selected. Images of the supratemporal and infratemporal retinal vessels in the B zones were obtained by SD-OCT, and the edges of the vessels were identified by the FWHM method. The internal and external diameters, wall thickness (WT), wall cross-sectional area (WCSA) and wall-to-lumen ratio (WLR) of the blood vessels were studied. RESULTS: Compared with the healthy control group, the POAG group showed a significantly reduced retinal arteriolar outer diameter (RAOD), retinal arteriolar lumen diameter (RALD) and WSCA in the supratemporal (124.22±12.42 138.32±10.73 µm, 96.09±11.09 108.53±9.89 µm, and 4762.02±913.51 5785.75±1148.28 µm, respectively, all <0.05) and infratemporal regions (125.01±15.55 141.57±10.77 µm, 96.27±13.29 110.83±10.99 µm, and 4925.56±1302.88 6087.78±1061.55 µm, all <0.05). The arteriolar WT and WLR were not significantly different between the POAG and control groups, nor were the retinal venular outer diameter (RVOD), retinal venular lumen diameter (RVLD) or venular WT in the supratemporal or infratemporal region. There was a positive correlation between the arteriolar parameters and visual function. CONCLUSION: In POAG, narrowing of the supratemporal and infratemporal arterioles and a significant reduction in the WSCA is observed, while the arteriolar WT and WLR do not change. Among the venular parameters, the external diameter, internal diameter, WT, WLR, and WSCA of the venules are not affected.
Zhejiang University School of Medicine, Hang Zhou 310030, Zhejiang Province, China.
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