advertisement
Abstract #10893 Published in IGR 6-2
Intraocular pressure in rabbits after administration of 10% L-arginine HCl in 2% Trusopt
Veselovsky J; Olah Z; Vesela A; Gressnerova SČeska a Slovenska Oftalmologie 2004; 60: 81-8
In this contribution publish the observation that addition of 10% L-arginin.HCl to the 2% Trusopt eye drops intensifies activity of antiglaucomatics with an important reduction of the normal intraocular pressure (IOP) in rabbits New Zealand white namely from 15 up to 240 minutes, compared with application of both substance alone. Size of the pupil was not affected. Based on our experimental results we assume that this increasing activity of Trusopt mixture with amino acid L-arginin.HCl created a new metabolite. According to our observations this metabolite caused reduction of the humor aqueous production and together with the increased of the uveo-scleral outflow leads to the striking reduction of the IOP. LA: Slovak
Katedra zivocisnej fyziologie a etologie Prif UK, Bratislava.
Classification:
11.14 Investigational drugs; pharmacological experiments (Part of: 11 Medical treatment)