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Abstract #110084 Published in IGR 24-1
Fecal calprotectin as an intestinal inflammation marker is elevated in glaucoma
Wang Z; Yuan H; Zhu X; Wang J; Xiu W; Chen Y; Zhang G; Fu J; Peng K; Li A; Liu D; Huang X; He C; Lu FBiomarkers in medicine 2023; 17: 465-473
The aim of this study was to investigate the potential association between glaucoma and fecal calprotectin. A total of 144 glaucomatous patients and 66 healthy controls were enlisted for this study. The fecal calprotectin was assessed using enzyme-linked immunosorbent assay. The median fecal calprotectin levels were significantly elevated in glaucoma (73.67 vs 41.97 μg/g; p < 0.001), primary angle-closure glaucoma (76.85 μg/g; p < 0.001) and primary open-angle glaucoma (69.29 μg/g; p = 0.016) groups compared with controls. A notable proportion of the glaucoma (24%; p < 0.001), primary angle-closure glaucoma (21%; p < 0.001) and primary open-angle glaucoma (24%; p < 0.001) subgroups exhibited highly abnormal fecal calprotectin levels (≥250 μg/g). Elevated fecal calprotectin might indicate potential intestinal inflammation in glaucoma.
Department of Clinical Laboratory, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science & Technology of China, Chengdu, China.
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