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Abstract #112545 Published in IGR 24-3
Single-nucleotide polymorphisms of and linked to primary open-angle glaucoma among patients of Shenyang, China
Jie J; Wu TExperimental biology and medicine (Maywood, N.J.) 2023; 248: 2319-2324
The potential for adverse outcomes and classifications of glaucoma differ among race, country, gender, and family medical history. Nearly, 50 represent candidate genes are considered as potential contributors to the happening for the primary open-angle glaucoma (POAG) since the advent of GWASs. Our investigation is the first to report the Toll-like receptor 4 () and growth arrest-specific 7 () among people in Shenyang, China; to investigate whether single-nucleotide polymorphisms (SNPs) in () or gene are risk factors for POAG among people in Shenyang, China; and also to explore their potential pathogenic mechanisms. POAG patients from July 2015 to June 2019 at Shenyang Fourth People's Hospital were selected. A total of 218 POAG patients and 252 controls were enrolled. Eight potentially functional SNPs of (rs7868859, rs7873784, rs77358523, and rs752998) and (rs8012311, rs11656696, rs74629981, and rs9900085) were genotyped. Multifactor analysis was conducted to evaluate the correlation between , , and POAG. The allele frequency of rs7873784 of demonstrated that the GC ( = 0.030), CC ( = 0.040), and GC + CC genotypes ( = 0.009) were significantly higher compared with CC genotype for POAG patients than that for controls. The rs8072311 and rs9900085 of gene also were significantly associated with POAG. Haplotype analysis found that the C-A-T-A haplotype (order: rs7873784-rs77358523-rs752998-rs7868859) of gene and the two haplotypes A-C-C-A and C-C-A-C of (order: rs9900085-rs74629981-rs8072311-rs11656696) were associated with an elevated susceptibility to POAG ( < 0.05). In this study, rs7868859 of and rs8012311 and rs9900085 polymorphisms of were first identified to be related to POAG among people in Shenyang, China.
Department of Ophthalmology, The Fourth People's Hospital of Shenyang, Shenyang 110031, P.R. China.
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