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Abstract #112795 Published in IGR 24-3
Association between optic atrophy 1 polymorphisms and primary open angle glaucoma risk: Based on a meta-analysis
Liu YF; Luo XY; Zhao ZC; Zheng W; Lv HY; Luo WMEuropean Journal of Ophthalmology 2023; 0: 11206721231208244
BACKGROUND: Emerging evidence suggested a significant association between optic atrophy 1 (OPA1) polymorphisms and primary open angle glaucoma (POAG) risk. However, the current data are inconsistent or even contradictory. Given these, we conducted a meta-analysis to examine the precise association between OPA1 polymorphisms and POAG risk. MATERIALS AND METHODS: Online databases were retrieved, and the related studies were reviewed from inception to December 1, 2022. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were calculated to examine the statistical power of each genetic model. In addition, heterogeneity, sensitivity, cumulative analysis, and publication bias were analyzed to guarantee statistical power. RESULT: Overall, 14 studies within 11 publications (involving 2,413 POAG patients and 1,904 controls) were included and some significant association between OPA1 rs166850 C/T (T vs. C: OR = 1.24, 95%CI = 1.06-1.45, = 0.01, I= 39.0%; CT vs. CC: OR = 1.37, 95%CI = 1.05-1.79, = 0.02, I= 41.6%; CT + TT vs. CC: 1.37, 95%CI = 1.06-1.77, = 0.02, I= 41.6%), rs10451941T/C (TC + CC vs. TT: OR = 1.79, 95%CI = 1.41-2.28, < 0.01, I= 71.9%) polymorphisms and POAG susceptibility. In addition, further significant associations were also observed in the stratified analysis, especially in normal tension glaucoma groups and Caucasian descendants. CONCLUSION: The observed evidences suggest that OPA1 polymorphisms may be associate with POAG susceptibility significantly.
Department of Ophthalmology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China.
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